What two diseases were most prominent in Jamestown? How did the location of the settlement play a role in the spread of these diseases? A) Malaria and dysentery; Mosquitoes thrived in the swampy surroundings B) Smallpox and influenza; Cold climate facilitated disease transmission C) Tuberculosis and cholera; Contaminated water sources contributed to the spread D) Yellow fever and typhoid; Overcrowded living conditions facilitated transmission